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You are studying the binding of proteins to the cytoplasmic face of cultured liver cells and have found a method that gives a good yield of inside-out vesicles from the plasma membrane. Unfortunately, your preparations are contaminated with variable amounts of right-side-out vesicles. Nothing you have tried avoids this contamination. Somebody suggests that you pass the vesicles over an affinity column made of lectin coupled to Sepharose beads. What is the rational of this suggestion?